Clinical Diagnostics

Clinical Study

& Publications

 

Clinical comparison of a NGS-based approach vs. conventional testing methods*

PathoQuest has completed a proof of concept clinical study which compared the ability of an NGS-based testing approach to identify pathogens in patients with suspected infections versus the use of conventional testing methodologies was conducted at two prominent medical centers in France. This study:

  • A total of 101 patients were enrolled in the study.
  • All patients enrolled were immunocompromised and 23% of the patients were neutropenic.
  • The study cohort included the following reasons for immunosuppression:

– Anti-cancer chemotherapy
– Immunosuppressive treatment following solid organ transplantation
– Stem cell transplant recipients
– Primitive immunodeficiency
– Other causes of immunosuppression

  • The study compared PathoQuest’s next-generation sequencing (NGS) based testing approach to standard testing methodologies (blood cultures and targeted PCR testing).
  • Testing results from both arms of the study were medically adjudicated by a panel of clinical experts in order to confirm that the pathogens identified were likely to be associated with the patient’s infection-related symptoms and clinical presentation.

The results of this study have been recently published in the peer-reviewed journal Clinical Microbiology and Infection, an official publication of ESCMID.

*Parize P, Muth E, Richaud C, et al. Untargeted next-generation sequencing-based first-line diagnosis of infection in immunocompromised adults: a multicentre, blinded, prospective study.Clin Microbiol Infect. 2017 Feb 10. doi: 10.1016/j.cmi.2017.02.006.

Publications

The following are peer-reviewed publications and presentations which provide information related to PathoQuest’s next-generation sequencing solution for the clinical identification of pathogens: Click on highlighted title for link to publication.

  • Phan NG, Gouilh MA,  JPaireau J, Do LP, Cheval J, Ngu ND, Hébert C, Nguyen TH, Lortholary O, Tondeur L, Manuguerra JC, Barouki R,  Sander J, Janzen N,  Nguyen HT, Brey PT, Fontanet A,  Eloit M. Hypoglycemic toxins and enteroviruses as distinct causes of pediatric acute encephalitis-like syndrome outbreaks in Bac Giang Province, northern Vietnam. Emerg Infect Dis. 2018, in press.
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